SERVIDOR DE PRUEBAS
Logotipo del repositorio

San Martin Barrientos, Aurelio Del Carmen

Cargando...
Miniatura
Nombre preferido
San Martin Barrientos, Aurelio Del Carmen
Nombre completo
San Martin Barrientos, Aurelio Del Carmen
AfiliaciĆ³n principal
Email
aurelio.sanmartin@umag.cl
ORCID
Jerarquƭa acadƩmica
Prof. Asociado/a
LĆ­nea de investigaciĆ³n
Otra lĆ­nea emergente
Buscar
Fecha de inicio: 2018Fecha de finalizaciĆ³n: 2019

Ajustes

Filtrar por:

2018 - 20194

Ajustes

Publicaciones

Mostrando 1 - 5 de 5
  • Some of the metrics are blocked by your 
    consent settings
    PublicaciĆ³n
    DOI 10.1016/j.bmc.2018.11.030
    Antileishmanial activity and cytotoxicity of ent-beyerene diterpenoids
    2019-01-01
    Murillo, Jilmar A.
    ;
    Gil, Juan F.
    ;
    Upegui, Yulieth A.
    ;
    Restrepo, Adriana M.
    ;
    Robledo, Sara M.
    ;
    Quinones, Winston
    ;
    Echeverri, Fernando
    ;
    San Martin Barrientos, Aurelio Del Carmen
    ;
    Olivo, Horacio F.
    ;
    Escobar, Gustavo
    We describe the in vitro activity of two natural isomeric ent-beyerene diterpenes, several derivatives and synthetic intermediates. Beyerenols 1 and 2 showed EC50 of 4.6 +/- 9.4 and 5.3 +/- 9.4 mu g/mL against amastigotes of L. (V) brazilensis, with SI of 5.1 and 7.7, respectively. Beyerenol 1 was synthesized from stevioside. In vivo experiments with bereyenols showed cure in 50% of hamsters infected with L. (V) brazilensis topically applied as Cream I (beyerenol 1, 0.81%, w/w) and Cream III (beyerenol 2, 1.96%, w/w). These results suggest that beyerenols are potential candidates for cutaneous leishmaniasis chemotherapy by topical application. In vitro assays of amastigotes of L. (V) brazilensis showed EC50 of 1.1 +/- 0.1 and 1.3 +/- 0.04 mu g/mL, with SI of 3.1 and 3.5 for hydrazone intermediates 10 and 11, respectively.
  • Some of the metrics are blocked by your 
    consent settings
    PublicaciĆ³n
    DOI 10.1016/j.bmc.2018.11.030
    Antileishmanial activity and cytotoxicity of ent-beyerene diterpenoids
    2019-01-01
    Murillo, Jilmar A.
    ;
    Gil, Juan F.
    ;
    Upegui, Yulieth A.
    ;
    Restrepo, Adriana M.
    ;
    Robledo, Sara M.
    ;
    Quinones, Winston
    ;
    Echeverri, Fernando
    ;
    San Martin Barrientos, Aurelio Del Carmen
    ;
    Olivo, Horacio F.
    ;
    Escobar, Gustavo
    We describe the in vitro activity of two natural isomeric ent-beyerene diterpenes, several derivatives and synthetic intermediates. Beyerenols 1 and 2 showed EC50 of 4.6 +/- 9.4 and 5.3 +/- 9.4 mu g/mL against amastigotes of L. (V) brazilensis, with SI of 5.1 and 7.7, respectively. Beyerenol 1 was synthesized from stevioside. In vivo experiments with bereyenols showed cure in 50% of hamsters infected with L. (V) brazilensis topically applied as Cream I (beyerenol 1, 0.81%, w/w) and Cream III (beyerenol 2, 1.96%, w/w). These results suggest that beyerenols are potential candidates for cutaneous leishmaniasis chemotherapy by topical application. In vitro assays of amastigotes of L. (V) brazilensis showed EC50 of 1.1 +/- 0.1 and 1.3 +/- 0.04 mu g/mL, with SI of 3.1 and 3.5 for hydrazone intermediates 10 and 11, respectively.
    ScopusĀ© Citations 26  2
  • Some of the metrics are blocked by your 
    consent settings
    PublicaciĆ³n
    DOI 10.4067/s0717-97072018000404200
    ANTIMICROBIAL ACTIVITIES OF DITERPENOWS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA
    2018-12
    Nunez, S.
    ;
    San Martin Barrientos, Aurelio Del Carmen
    ;
    Corsini, G.
    The antibacterial activity of two natural diterpenoids isolated from Azorella compacta together with six semisynthetic derivatives, were evaluated against three bacteria: Staphylococcus aureus. Escherichia coli and Mycobacterium smegmatis. The synthesis of the semisynthetic derivatives 3-5 and 8 have not been previously reported with the methods described in this research. The structures of all diterpenoids were elucidated by NMR H-1,C- 13 and IR spectroscopy. The natural diterpenoids, mulinolic acid (1) and azorellanol (2) did not present antibacterial activity, but the six derivatives: 12-oxo-11,13-alpha,alpha-dihydroxymulin-20-oic acid (3), 11-oxo-12,13-alpha,alpha-dihydroxymulin-20-oic acid (4) 11,12-dioxo-13-alpha-hydroxymulin-20-oic acid (5). 7-acetoxymulin-9,12-diene (6). mulin-9,12-dien-7-ol (7) and 7-acetoxy-12,13-dihydroxymulin-9-en (8) were active against three tested bacteria. The antibacterial activity reported for six semisynthetic diterpenoids may not be comparable with positive control ampicillin but demonstrate the possibility of modification of the biological activity of diterpenoids.
    ScopusĀ© Citations 5  1
  • Some of the metrics are blocked by your 
    consent settings
    PublicaciĆ³n
    DOI 10.4067/s0717-97072018000304082
    A NOVEL NORMULINANE ISOLATED FROM Azorella compacta AND ASSESSMENT OF ITS ANTIBACTERIAL ACTIVITY
    2018
    San Martin Barrientos, Aurelio Del Carmen
    ;
    Bacho, M.
    ;
    NĆŗƱez, S.
    ;
    Rovirosa, J.
    ;
    Soler, A.
    ;
    Blanc, V.
    ;
    LeĆ³n, R.
    ;
    Olea, A. F.
    ABSTRACT Phytochemical analysis of Azorella compacta resulted in the isolation of six known diterpenes and one unknown norditerpene using chromatographic methods. The structure of this new compound was established by spectroscopic analysis. The bioactivity of the new compound was assessed against six oral bacteria using a drop test method. A high level of growth inhibition was observed against F. nucleatum and P. gingivalis; however, other species such as V. parvula and A. actinomycetemcomitans were not affected.
    ScopusĀ© Citations 7  1
  • Some of the metrics are blocked by your 
    consent settings
    PublicaciĆ³n
    DOI 10.1016/j.phytochem.2017.06.010
    A set of biogenetically interesting polyhalogenated acetogenins from &ITPtilonia magellanica&IT
    2018-1
    Gallardo Ovando, Amalia Beatriz
    ;
    Cueto, Mercedes
    ;
    Diaz-Marrero, Ana R.
    ;
    de la Rosa, Jose M.
    ;
    Fajardo Morales, Victor Manuel
    ;
    San Martin Barrientos, Aurelio Del Carmen
    ;
    Darias, Jose
    Ptilonines A-F, pyranosylmagellanicus D-E and magellenediol are previously undescribed acetogenins isolated from the red alga Ptilonia magellanica. Their structures were determined from spectroscopic evidence. The absolute configuration of the known pyranosylmagellanicus A, was established by derivatization with (R)- and (S)-alpha-methoxy -alpha-phenylacetic acids (MPA). Ptilonines exhibit an unusual halogenation pattern, that may confer evolutionary advantages to Ptilonia magellanica, for which a biogenetic origin is proposed. The antimicrobial effect of some of these compounds was evaluated. (C) 2017 Elsevier Ltd. All rights reserved.
    ScopusĀ© Citations 5  3
Sugerencias y
Reporte de errores