A set of biogenetically interesting polyhalogenated acetogenins from &ITPtilonia magellanica&IT
Darias, Jose
- 1
- 2Consejo Superior de Investigaciones Cientificas (CSIC)
Journal
phytochemistry
ISSN
0031-9422
Open Access
closed
Volume
145
Start page
111
End page
120
Ptilonines A-F, pyranosylmagellanicus D-E and magellenediol are previously undescribed acetogenins isolated from the red alga Ptilonia magellanica. Their structures were determined from spectroscopic evidence. The absolute configuration of the known pyranosylmagellanicus A, was established by derivatization with (R)- and (S)-alpha-methoxy -alpha-phenylacetic acids (MPA). Ptilonines exhibit an unusual halogenation pattern, that may confer evolutionary advantages to Ptilonia magellanica, for which a biogenetic origin is proposed. The antimicrobial effect of some of these compounds was evaluated. (C) 2017 Elsevier Ltd. All rights reserved.