San Martin Barrientos, Aurelio Del Carmen
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San Martin Barrientos, Aurelio Del Carmen
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San Martin Barrientos, Aurelio Del Carmen
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aurelio.sanmartin@umag.cl
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JerarquĆa acadĆ©mica
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Otra lĆnea emergente
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PublicaciĆ³n DOI 10.1080/14786419.2021.1946534Synthesis, characterisation, crystal structure and antimicrobial evaluation of novel 6-alkoxyergosta-4,6,8(14),22-tetraen-3-one derived from natural ergosta-5,7,22-trien-3Ī²-ol2023-01-02; In this study, we report a facile transformation starting from 5 alpha-hydroxyergosta-7,22-dien-3,6-dione (1) to afford two novel compounds: 6-methoxyergosta-4,6,8(14),22-tetraen-3-one (2) and 6-ethoxyergosta-4,6,8(14),22-tetraen-3-one (3) using alcoholic acid catalysis. Their structures were elucidated using NMR experiments, FT-IR, MS and X-ray analysis. These compounds were evaluated for antibacterial activity using the disk and broth diffusion test. In those tests, compound 3 was found to be the most significant antibacterial agent. In general, compounds 1-3 showed inhibition zone in the range of 7.00-12.3 mm for S. aureus and S. mutans, meanwhile for Gram-negative bacteria E. coli and Pseudomonas sp. was found to be in the range of 7.00-8.00 mm. For the most active, compound 3, MIC was significantly lower than that reported for ergosterol, in a value of 160 mu g/mL. Overall, these compounds were more active than their natural precursor. - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.1080/14786419.2021.1946534Synthesis, characterisation, crystal structure and antimicrobial evaluation of novel 6-alkoxyergosta-4,6,8(14),22-tetraen-3-one derived from natural ergosta-5,7,22-trien-3Ī²-ol2023-01-02; In this study, we report a facile transformation starting from 5 alpha-hydroxyergosta-7,22-dien-3,6-dione (1) to afford two novel compounds: 6-methoxyergosta-4,6,8(14),22-tetraen-3-one (2) and 6-ethoxyergosta-4,6,8(14),22-tetraen-3-one (3) using alcoholic acid catalysis. Their structures were elucidated using NMR experiments, FT-IR, MS and X-ray analysis. These compounds were evaluated for antibacterial activity using the disk and broth diffusion test. In those tests, compound 3 was found to be the most significant antibacterial agent. In general, compounds 1-3 showed inhibition zone in the range of 7.00-12.3 mm for S. aureus and S. mutans, meanwhile for Gram-negative bacteria E. coli and Pseudomonas sp. was found to be in the range of 7.00-8.00 mm. For the most active, compound 3, MIC was significantly lower than that reported for ergosterol, in a value of 160 mu g/mL. Overall, these compounds were more active than their natural precursor.ScopusĀ© Citations 2 2 - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.4067/s0717-97072022000405737PHYTOCHEMICAL STUDY ON ECTOMYCORRHIZAL FUNGI Cortinarius Magellanicus: AN UNUSUAL BROMINATED SECONDARY METABOLITE ISOLATED2022-11-01; Phytochemical analysis of the basidiomycete Cortinarius magellanicus (family Cortinariaceae) resulted in the isolation of eight secondary metabolites, where a brominated secondary metabolite was isolated for first time from a natural source. The structure elucidation of this compound was made using one- and two-dimensional NMR experiments, FT-IR, GC-MS, HRESIMS and chemical derivation. The disk diffusion assay of the brominated compound 4 and 8 revealed a low inhibition on Gram-positive and Gram-negative bacteria, respectively. No antifungal activities were detected for these compounds. - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.4067/s0717-97072022000405737PHYTOCHEMICAL STUDY ON ECTOMYCORRHIZAL FUNGI Cortinarius Magellanicus: AN UNUSUAL BROMINATED SECONDARY METABOLITE ISOLATED2022-11-01; Phytochemical analysis of the basidiomycete Cortinarius magellanicus (family Cortinariaceae) resulted in the isolation of eight secondary metabolites, where a brominated secondary metabolite was isolated for first time from a natural source. The structure elucidation of this compound was made using one- and two-dimensional NMR experiments, FT-IR, GC-MS, HRESIMS and chemical derivation. The disk diffusion assay of the brominated compound 4 and 8 revealed a low inhibition on Gram-positive and Gram-negative bacteria, respectively. No antifungal activities were detected for these compounds.ScopusĀ© Citations 1 1 - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.1016/j.bmc.2018.11.030Antileishmanial activity and cytotoxicity of ent-beyerene diterpenoids2019-01-01; - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.1016/j.bmc.2018.11.030Antileishmanial activity and cytotoxicity of ent-beyerene diterpenoids2019-01-01; ScopusĀ© Citations 26 2 - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.4067/s0717-97072018000404200
ANTIMICROBIAL ACTIVITIES OF DITERPENOWS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA2018-12; Corsini, G.The antibacterial activity of two natural diterpenoids isolated from Azorella compacta together with six semisynthetic derivatives, were evaluated against three bacteria: Staphylococcus aureus. Escherichia coli and Mycobacterium smegmatis. The synthesis of the semisynthetic derivatives 3-5 and 8 have not been previously reported with the methods described in this research. The structures of all diterpenoids were elucidated by NMR H-1,C- 13 and IR spectroscopy. The natural diterpenoids, mulinolic acid (1) and azorellanol (2) did not present antibacterial activity, but the six derivatives: 12-oxo-11,13-alpha,alpha-dihydroxymulin-20-oic acid (3), 11-oxo-12,13-alpha,alpha-dihydroxymulin-20-oic acid (4) 11,12-dioxo-13-alpha-hydroxymulin-20-oic acid (5). 7-acetoxymulin-9,12-diene (6). mulin-9,12-dien-7-ol (7) and 7-acetoxy-12,13-dihydroxymulin-9-en (8) were active against three tested bacteria. The antibacterial activity reported for six semisynthetic diterpenoids may not be comparable with positive control ampicillin but demonstrate the possibility of modification of the biological activity of diterpenoids.ScopusĀ© Citations 5 1 - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.4067/s0717-97072018000304082A NOVEL NORMULINANE ISOLATED FROM Azorella compacta AND ASSESSMENT OF ITS ANTIBACTERIAL ACTIVITY2018; ScopusĀ© Citations 7 1 - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.3390/md21020098Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance2023-2; ScopusĀ© Citations 11 2 - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.3390/md20050337Secondary Metabolites Isolated from Chilean Marine Algae: A Review2022-5; Taborga, LautaroChile is in the extreme southwestern part of America, and it has an extreme length, of approximately 4300 km that increases to 8000 km considering the Chilean Antarctic Territory. Despite the large extent of its coastal territory and the diversity of geographic environments and climates associated with Chilean coasts, the research on marine resources in Chile has been rather scarce. From marine organisms found in Chilean coastal waters, algae have been the most studied, since they contain a wide range of interesting secondary metabolites that have some structural traits that make them unique and uncharacteristic. Thus, a wide structural variety of natural products including terpenoids (monoterpenes, sesquiterpenes, diterpenes, and meroterpenoids), furanones, and C-15-acetogenins have been isolated and identified. This review describes the existing literature on bioprospecting and exploration of secondary metabolites from Chilean coasts.ScopusĀ© Citations 8 2