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San Martin Barrientos, Aurelio Del Carmen

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San Martin Barrientos, Aurelio Del Carmen
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San Martin Barrientos, Aurelio Del Carmen
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aurelio.sanmartin@umag.cl
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    Publicación
    DOI 10.4067/s0717-97072018000404200
    ANTIMICROBIAL ACTIVITIES OF DITERPENOWS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA
    2018-12
    Nunez, S.
    ;
    San Martin Barrientos, Aurelio Del Carmen
    ;
    Corsini, G.
    The antibacterial activity of two natural diterpenoids isolated from Azorella compacta together with six semisynthetic derivatives, were evaluated against three bacteria: Staphylococcus aureus. Escherichia coli and Mycobacterium smegmatis. The synthesis of the semisynthetic derivatives 3-5 and 8 have not been previously reported with the methods described in this research. The structures of all diterpenoids were elucidated by NMR H-1,C- 13 and IR spectroscopy. The natural diterpenoids, mulinolic acid (1) and azorellanol (2) did not present antibacterial activity, but the six derivatives: 12-oxo-11,13-alpha,alpha-dihydroxymulin-20-oic acid (3), 11-oxo-12,13-alpha,alpha-dihydroxymulin-20-oic acid (4) 11,12-dioxo-13-alpha-hydroxymulin-20-oic acid (5). 7-acetoxymulin-9,12-diene (6). mulin-9,12-dien-7-ol (7) and 7-acetoxy-12,13-dihydroxymulin-9-en (8) were active against three tested bacteria. The antibacterial activity reported for six semisynthetic diterpenoids may not be comparable with positive control ampicillin but demonstrate the possibility of modification of the biological activity of diterpenoids.
    Scopus© Citations 5  1
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    Publicación
    DOI 10.4067/s0717-97072018000304082
    A NOVEL NORMULINANE ISOLATED FROM Azorella compacta AND ASSESSMENT OF ITS ANTIBACTERIAL ACTIVITY
    2018
    San Martin Barrientos, Aurelio Del Carmen
    ;
    Bacho, M.
    ;
    Núñez, S.
    ;
    Rovirosa, J.
    ;
    Soler, A.
    ;
    Blanc, V.
    ;
    León, R.
    ;
    Olea, A. F.
    ABSTRACT Phytochemical analysis of Azorella compacta resulted in the isolation of six known diterpenes and one unknown norditerpene using chromatographic methods. The structure of this new compound was established by spectroscopic analysis. The bioactivity of the new compound was assessed against six oral bacteria using a drop test method. A high level of growth inhibition was observed against F. nucleatum and P. gingivalis; however, other species such as V. parvula and A. actinomycetemcomitans were not affected.
    Scopus© Citations 7  1
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