San Martin Barrientos, Aurelio Del Carmen
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San Martin Barrientos, Aurelio Del Carmen
Nombre completo
San Martin Barrientos, Aurelio Del Carmen
AfiliaciĆ³n principal
Email
aurelio.sanmartin@umag.cl
ORCID
JerarquĆa acadĆ©mica
Prof. Asociado/a
LĆnea de investigaciĆ³n
Otra lĆnea emergente
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4 resultados
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PublicaciĆ³n DOI 10.1080/14786419.2021.1946534Synthesis, characterisation, crystal structure and antimicrobial evaluation of novel 6-alkoxyergosta-4,6,8(14),22-tetraen-3-one derived from natural ergosta-5,7,22-trien-3Ī²-ol2023-01-02; In this study, we report a facile transformation starting from 5 alpha-hydroxyergosta-7,22-dien-3,6-dione (1) to afford two novel compounds: 6-methoxyergosta-4,6,8(14),22-tetraen-3-one (2) and 6-ethoxyergosta-4,6,8(14),22-tetraen-3-one (3) using alcoholic acid catalysis. Their structures were elucidated using NMR experiments, FT-IR, MS and X-ray analysis. These compounds were evaluated for antibacterial activity using the disk and broth diffusion test. In those tests, compound 3 was found to be the most significant antibacterial agent. In general, compounds 1-3 showed inhibition zone in the range of 7.00-12.3 mm for S. aureus and S. mutans, meanwhile for Gram-negative bacteria E. coli and Pseudomonas sp. was found to be in the range of 7.00-8.00 mm. For the most active, compound 3, MIC was significantly lower than that reported for ergosterol, in a value of 160 mu g/mL. Overall, these compounds were more active than their natural precursor. - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.1080/14786419.2021.1946534Synthesis, characterisation, crystal structure and antimicrobial evaluation of novel 6-alkoxyergosta-4,6,8(14),22-tetraen-3-one derived from natural ergosta-5,7,22-trien-3Ī²-ol2023-01-02; In this study, we report a facile transformation starting from 5 alpha-hydroxyergosta-7,22-dien-3,6-dione (1) to afford two novel compounds: 6-methoxyergosta-4,6,8(14),22-tetraen-3-one (2) and 6-ethoxyergosta-4,6,8(14),22-tetraen-3-one (3) using alcoholic acid catalysis. Their structures were elucidated using NMR experiments, FT-IR, MS and X-ray analysis. These compounds were evaluated for antibacterial activity using the disk and broth diffusion test. In those tests, compound 3 was found to be the most significant antibacterial agent. In general, compounds 1-3 showed inhibition zone in the range of 7.00-12.3 mm for S. aureus and S. mutans, meanwhile for Gram-negative bacteria E. coli and Pseudomonas sp. was found to be in the range of 7.00-8.00 mm. For the most active, compound 3, MIC was significantly lower than that reported for ergosterol, in a value of 160 mu g/mL. Overall, these compounds were more active than their natural precursor.ScopusĀ© Citations 2 2 - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.4067/s0717-97072022000405737PHYTOCHEMICAL STUDY ON ECTOMYCORRHIZAL FUNGI Cortinarius Magellanicus: AN UNUSUAL BROMINATED SECONDARY METABOLITE ISOLATED2022-11-01; Phytochemical analysis of the basidiomycete Cortinarius magellanicus (family Cortinariaceae) resulted in the isolation of eight secondary metabolites, where a brominated secondary metabolite was isolated for first time from a natural source. The structure elucidation of this compound was made using one- and two-dimensional NMR experiments, FT-IR, GC-MS, HRESIMS and chemical derivation. The disk diffusion assay of the brominated compound 4 and 8 revealed a low inhibition on Gram-positive and Gram-negative bacteria, respectively. No antifungal activities were detected for these compounds. - Some of the metrics are blocked by yourconsent settings
PublicaciĆ³n DOI 10.4067/s0717-97072022000405737PHYTOCHEMICAL STUDY ON ECTOMYCORRHIZAL FUNGI Cortinarius Magellanicus: AN UNUSUAL BROMINATED SECONDARY METABOLITE ISOLATED2022-11-01; Phytochemical analysis of the basidiomycete Cortinarius magellanicus (family Cortinariaceae) resulted in the isolation of eight secondary metabolites, where a brominated secondary metabolite was isolated for first time from a natural source. The structure elucidation of this compound was made using one- and two-dimensional NMR experiments, FT-IR, GC-MS, HRESIMS and chemical derivation. The disk diffusion assay of the brominated compound 4 and 8 revealed a low inhibition on Gram-positive and Gram-negative bacteria, respectively. No antifungal activities were detected for these compounds.ScopusĀ© Citations 1 1