Acceso Cerrado
A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea
- 1University of Geneva
- 2
- 3University of Basel
- 4
Revista
natural product research
ISSN
1478-6419
1478-6427
Acceso abierto
closed
Volumen
32
Página de inicio
695
Página final
701
A new bibenzyl derivative (4), together with two glycosylated flavonoids (1 and 2), batatasin III (3) and the phenanthrene isohircinol (5) were isolated from the aerial parts of Gavilea lutea. Their structures were elucidated on the basis of spectroscopic studies including 1D and 2D NMR, UV, IR and HRESIMS. All isolated compounds were evaluated for their antifungal activity towards Candida albicans. The new compound 4 showed inhibitory activity with a MIQ of 50 mu g. In addition, compound 4 exhibited a selective activity (IC50 = 2.3 mu g/mL) against Leishmania donovani. [GRAPHICS] .